Bleeding Time
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The bleeding time test is approximately 170
years old and was developed even before platelets were recognized as normal blood
elements. The test was used to evaluate patients who presented with purpura. Current
thinking is that the test evaluates platelet function, provided that the platelet numbers
are adequate. There are a few reports of prolongation in coagulation factor deficiencies
and with patients on heparin.
The test has very poor sensitivity. For
example, the test will detect only 27% of patients with von Willebrands syndrome
(whereas symptoms alone have a sensitivity to von Willebrands of 65%). To
investigate bleeding, take a good history and use this test as part of a battery of tests.
Our reference range is 1-9 minutes but given a
positive history of bleeding, be suspicious in the borderline area ( 7 min.). The test
lacks sensitivity therefore, you should fully investigate all abnormal findings. It
is very difficult to define false positives as many bleeding tendencies are never fully
explained with todays models.
Evaluations of the bleeding time indicate that you should not use the
test:
- for preoperative screening.
- to rule out a bleeding disorder (for example: to prove child abuse).
- to clear a patient for surgery given clinical evidence of bleeding, other laboratory
abnormality(ies) or a positive history of bleeding.
The test is simply too insensitive and misses over three-fourths of bleeding disorders
due to platelet dysfunction.
The bottom line? As originally intended, use this test to investigate
purpura. Do not use the test to predict bleeding nor to justify other procedures. Normal
results are practically meaningless. A good history has been shown, repeatedly, to be more
sensitive to bleeding disorders than any hemostatic screening test.
Suggested Reading
- Rodgers C, Levin J. A Critical Reappraisal of the Bleeding Time. Seminars in Thrombosis
and Hemostasis. 1990;16:9-14.
- Caterina R, et al. Bleeding Time and Bleeding: An Analysis of the Realtionship of the
Bleeding Time Test With Paramenters of Surgical Bleeding. Blood. 1994; 84: 3363-3369.
- Houry S, et al. A Prospective Multicenter Evaluation of Preoperative Hemostatic
Screening Tests. The American Journal of Surgery. 1995;170: 19-23.